Spider-Man Wallpaper, #1855

Orphaned at an early age, Peter Parker (Maguire) lives in Queens, New York with his beloved Aunt May (Harris) and Uncle Ben (Robertson). Peter leads the life of a normal student, working as a photographer at the Daily Bugle under the tutelage of publisher J. Jonah Jameson (Simmons), pining after the beautiful Mary Jane Watson (Dunst) and hanging out with his buddy Harry Osborn (Franco).

On a school trip, during which Peter and his classmates are given a science demonstration on spiders, Peter is bitten by a genetically altered spider. Soon after, he discovers that he has unusual powers: he is endowed with the strength and agility of a spider along with a keen, ESP-like "spider-sense." After discovering these powers, Peter appears in a televised wrestling match and, armed with his new spider strength, wins the match in record time. But the wrestling match promoter refuses to award Peter the $3,000 prize money, alleging that Peter won too quickly. Soon afterwards, Peter has the opportunity to catch a burglar fleeing from the promoter's office, but because he wants revenge, he refuses to stop him. Moments later, the same burglar kills his beloved Uncle Ben.
As Spider-Man, Peter apprehends the burglar but is plagued with guilt for not being a hero sooner. During his time of turmoil, Peter remembers something Uncle Ben once told him: "With great power, comes great responsibility." Peter takes this to heart and decides to use his extraordinary powers to fight crime.

Meanwhile, megalomaniacal businessman Norman Osborn (Dafoe), Harry's father, is undergoing some changes of his own. An experimental formula has blown up in his face, increasing his intelligence and strength but also driving him insane. He is now the Green Goblin, Spider-Man's arch-enemy, who will put young Peter Parker's vow to fight crime and help innocent people to the ultimate test.